Medications can pollute lakes, streams, and other water sources, affecting both wildlife and local drinking water. Some medications can impede reproduction in frogs, fish, and other aquatic animals. Even scarier, bacteria exposed to flushed antibiotics will attempt to adapt, which could lead to antibiotic-resistant bacteria. Unlike other items on the list, it’s not recommended to simply toss medications in the trash, as they can also pollute landfills or wind up in the hands of children or people who may abuse them. The FDA instead recommends dropping medications off at drug take-back location or, if unavailable, removing any identifying packaging, mixing them with an “unappealing substance” like that kitty litter you didn’t flush, wrapping it all in plastic, and throwing it in the trash.