If financial hardship prevents you from paying the full amount owed, you can apply for an offer in compromise. This is a negotiation with the IRS to pay less than the full amount you owe on your taxes.
Generally, the IRS accepts around 36% of the offers in compromise requests, so you may be better off if you can manage an installment plan.
To qualify for requesting an offer in compromise, you must be current on your tax filings and have no open bankruptcy proceedings. There is a $205 application fee, which may be waived for low-income individuals. You can choose to make a lump sum payment or periodic payments, if your request is accepted.